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Studies of developing cervical neoplasms

Studies of developing cervical neoplasms

Obstetrics and Gynecology 4(4): 411-417

Related cell-behavior studies were undertaken using the tissue-culture method, which makes it possible to study certain functional and structural properties of tumor cells by isolating them in cultures removed from the influence of the host and comparing them with normal cells of similar origin. Growing tissues in vitro often contributes to the differential diagnosis of doubtful tumors. These studies indicate that tissue-culture methods can demonstrate tissue activity and reflect the cytologic grades of abnormal growths. The more anaplastic the cervical tissue cells are, the greater their activity in culture and the shorter the time for epithelial cell migration with more frequent cell division. There is a gradation of tissue activity from the nearocarcinoma (precancer) stage to clinical cancer of the cervix. Cervical tissues derived from patients showing the precancer cell complex exhibit marked cell activity midway between normal and clinical cancer. Cancer in situ behaves in tissue culture similarly to clinical cancer, the difference being that outgrowth is slightly slower. In vitro studies utilizing the tissue-culture method provide a useful method of observing cell behavior and of measuring velocity of growth in human cervical neoplasms.

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Accession: 025544046

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PMID: 13203868

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