Studies of the Antibody Nature of the Rheumatoid Factor. Reaction of the Rheumatoid Factor with Human Specific Precipitates and with Native Human Gamma Globulin

Aho, K.; Simons, K.

Arthritis and Rheumatism 6: 676-688


ISSN/ISBN: 2326-5191
PMID: 14104052
DOI: 10.1002/art.1780060603
Accession: 025546736

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The reaction of the Rf with diphtheria toxoid-human antitoxin precipitates was studied. All the Rf activity from different rheumatoid sera was absorbed to the specific precipitates. This absorption was not markedly inhibited by even a large excess of added serum gamma globulin. The reaction of the Rf with the specific precipitates was found to be reversible. The dissociation reaction was studied quantitatively by using I131-labeled rheumatoid serum.