Studies on adipose tissue from obese patients with or without diabetes mellitus. II. Basal and insulin-stimulated glucose metabolism

Björntorp, P.

Acta Medica Scandinavica 179(2): 229-234

1966


ISSN/ISBN: 0001-6101
PMID: 5932061
DOI: 10.1111/j.0954-6820.1966.tb05452.x
Accession: 025552972

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Abstract
Subcutaneous adipose tissue from controls, obese and diabetic obese patients was incubated in vitro, and glucose uptake and incorporation of label from glucose-1-14C into carbon dioxide and lipid were measured in the basal state and after adding insulin. Glucose uptake per adipose tissue cell was increased in both the obese groups as compared with the controls. In non-diabetic obesity this corresponded to an increase of incorporation of label into carbon dioxide and lipid, a result compatible with an enhanced insulin effect on adipose tissue. The diabetic tissues showed no increase in incorporation, nor was there an increase in oxidation of glucose-1-14C to carbon dioxide after stimulation with insulin as occurred in the non-diabetic groups.

Studies on adipose tissue from obese patients with or without diabetes mellitus. II. Basal and insulin-stimulated glucose metabolism