Studies on adjuvant-induced polyarthritis in rats. II. Histogenesis of joint and visceral lesions
Jones, R.S.; Ward, J.R.
Arthritis and Rheumatism 6: 23-35
ISSN/ISBN: 2326-5191 PMID: 13964798 DOI: 10.1002/art.1780060104
Mycobacterium butyricum in olive oil was injected intradermally and the sequential histologic changes in viscera and joints determined. Foci of suppuration in viscera occurred concomitantly with the onset of suppurative arthritis and periarthritis. The acute visceral lesions underwent healing by the time of onset of macroscopic polyarthritis. These observations are interpreted as evidence for an important infectious component in adjuvant-induced disease.