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Studies on inactivated rabies vaccine of chick embryo origin. I. Various methods of inactivation

Oshima, Y.

Japanese Jour Bact 14(4): 321-331

1959

Accession: 025561053
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An inactivated rabies vaccine was prepared from the Nishigahara strain of the fixed virus subcultured from 20 to 30 generations in the chorioallantoic cavity of 5-6-day-old developing eggs. The inactivation of suspensions of infected embryos (LD50=10-6.0-10-7.3) was performed by various methods and their effects on immunogenicity were compared. The immunogenicity of chick embryo virus was greatly reduced when inactivated by phenol at 25[degree] C, a method recommended for rabbit brain virus. A usable vaccine with high immunogenicity could be produced only when the virus suspended in cystine or cysteine-containing medium was inactivated by merthiolate, or when the inactivation was done by UV rays. Extracts of normal or infected chick embryo tissues, except the brain, contained a substance which markedly reduced the immunogenicity of rabbit or sheep brain virus when added during the inactivation by phenol.

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