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The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
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Studies on oligosaccharide sulfates and monosaccharide sulfates for medical purposes: II. Antipeptic and antiulcerogenic properties of the tri, tetra-saccharide sulfates, monosaccharide sulfatas and sulfates


Studies on oligosaccharide sulfates and monosaccharide sulfates for medical purposes: II. Antipeptic and antiulcerogenic properties of the tri, tetra-saccharide sulfates, monosaccharide sulfatas and sulfates



Yakugaku Zasshi J Pharm Soc Jap 87(7): 778-780



Pepsin-inhibition and peptic ulcer inhibition in pylorusligated rats were examined in vitro using stachyose and raffinose sulfates as oligosaccharide esters, glucose, sorbitol, and glucosaminol sulfates as sulfates of monosaccharide and its reduced compound. Even monosaccharides and their reduced compounds, which have the lowest molecular weight among saccharides, showed a slight anti-pepsin and anti-ulcer actions when highly sulfated. There was no difference in the anti-ulcer action between O-sulfates and N-sulfates. Anti-pepsin and anti-ulcer actions became stronger as the degree of polymerization increased to tri- and tetrasaccharides, even when sulfur content was low. These experiments showed that the sulfate group played a chief rdle as the main active group in the appearance of anti-ulcer action in the sulfate esters of saccharides, and that the degree of molecular polymerization worked as a supplementary factor in increasing this action.

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Studies on oligosaccharide sulfates and monosaccharide sulfates for medical purposes. II. Antipeptic and antiulcerogenic properties of the tri, tetra-saccharide sulfates, monosaccharide sulfates and sulfates of its reduced products. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 87(7): 778-780, 1967

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