+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Studies on synthetic polypeptide antigens. II. The immunochemical properties of a group of linear synthetic polypeptides



Studies on synthetic polypeptide antigens. II. The immunochemical properties of a group of linear synthetic polypeptides



Jour Biol Chem 236(10): 2677-2683



A group of linear synthetic polypeptides consisting of different combinations of L-glutamic acid, L-lysine, L-tyrosine, and L-phenylalanine, and in the molecular weight range 50,000 to 100,000, elicit the production of precipitating antibodies and Arthus skin reactions in the rabbit; they are poor antigens in guinea pigs. The minimal requirement for anti-genicity in the polypeptides tested is the presence of glutamic acid and lysine (64). Neither polylysine nor polyglutamic acid will elicit the production of precipitating antibodies. The presence of tyrosine or phenylalanine in the polypeptide changes the magnitude of the antibody response and of the skin reactivity. The most powerful antigen contained glutamic acid, lysine, and 6% tyrosine. All of the polypeptides containing glutamic acid and lysine cross-reacted to a large but variable extent with each of the different antisera.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 025569100

Download citation: RISBibTeXText


Related references

Studies on synthetic polypeptide antigens. IX. The antigenicity of a new group of linear synthetic polypeptides. Journal of Biological Chemistry 238: 1373-1379, 1963

Studies on synthetic polypeptide antigens. XVII. Immunochemical properties of synthetic polypeptide-antibody systems. Immunology 12(6): 655-666, 1967

Studies on Synthetic Polypeptide Antigens. 13. the Effects of Systematic Variation in Composition and Chemical Modifications of the Synthetic Polypeptides on the Antibody-Synthetic Polypeptide Antigen Interaction. Journal of Biological Chemistry 239: 3083-3092, 1964

Studies on synthetic polypeptide antigens. XIII. The effects of systematic variation in composition and chemical modifications of the synthetic polypeptides on the antibody-synthetic polypeptide antigen interaction. J Biol Chem 239(9): 3083-3092, 1964

Studies on Synthetic Polypeptide Antigens. Xi. the Antigenicity of Optically Isomeric Synthetic Polypeptides. Journal of Biological Chemistry 239: 1107-1113, 1964

Studies on synthetic polypeptide antigens. 18. The role of composition, charge, and optical isomerism in the immunogenicity of synthetic polypeptides. Journal of Biological Chemistry 242(14): 3308-3318, 1967

Studies on synthetic polypeptide antigens. XV. The immunochemical properties of ferrocenyl-poly Glu-58Lys-36Tyr-6 (no. 2) conjugates. Journal of Immunology 96(5): 906-912, 1966

Studies on synthetic polypeptide antigens. XX. Genetic control of the antibody response in the rat to structurally different synthetic polypeptide antigens. Journal of Immunology 101(4): 730-742, 1968

Studies on synthetic polypeptide antigens. XIX. Immunogenicity and antigenic site structure of intramolecularly cross-linked polypeptides. Journal of Biological Chemistry 243(2): 287-300, 1968

Studies on synthetic polypeptide antigens XVI The immunogenicity of synthetic polypeptide aggregates. Biochimica et Biophysica Acta (BBA) - General Subjects 124(2): 374-379, 1966

Studies on Synthetic Polypeptide Antigens. Xii. the Effects of Ph, Ionic Strength, Temperature, and Nonaqueous Solvents on Antibody Activity and the Antibody-Synthetic Polypeptide Interaction. Journal of Biological Chemistry 239: 3071-3082, 1964

Studies on synthetic polypeptide antigens. VIII. The inhibition of the antibody-synthetic polypeptide reaction by amino acids, dipeptides, amines, alcohols, and dicarboxylic acids. Journal of Biological Chemistry 238: 108-123, 1963

Biochemical studies on synthetic polypeptides: I. Immunochemical studies on polypeptides. II: Effect of polypeptides on proteolysis. Dissertation Absts 18(5): 1599-1600, 1958

Studies on synthetic polypeptide antigens: XVIII. The role of composition, charge, and optical isomerism in the immunogenicity of synthetic poly-peptides. J Biol Chem 242(14): 3308-3318, 1967

Immunochemical Studies of Lipids. I. Preparation and Immunological Properties of Synthetic Psychosine-Protein Antigens. Journal of Biochemistry 54: 444-451, 1963