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Studies on the HST virus isolated from Yoshida tumor



Studies on the HST virus isolated from Yoshida tumor



Cancer Res 13(2): 119-124



The authors succeeded in isolating the milk factor virus of mammary cancer of the mouse from the tumor ascites. Antisera produced by the appln. of this virus inhibited the growth of the ascites tumor. These inhibited tumor cells regained their malignant characteristics when the virus was re-introduced. Reproduction of the ascites tumor by the administration of the virus to rats has been unsuccessful, although the HST virus after about 40 successive transmissions acquired a progressively more viscerotropic character and caused a chronic inflammation of the granulomatous type in the omentum, the liver, the spleen, the lymph nodes, the lungs, etc. Mice inoculated with the virus often showed anaplastic growth of peritoneal serous cells and produced an ascites which occasionally produced an ascites tumor containing neoplastic cells derived from the peritoneum. The mouse ascites tumor closely resembles that of rats from which the virus has been isolated.

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