Studies on the chromosomes of sarcoma 3-B

Jin, H.

Hirosaki Med Jour 15(2): 298-309


Accession: 025574276

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The chromosomes of Sarcoma 3-B were studied through the successive intraperitoneal transplantations. In the earlier generations, tumor cells of diploid and tetraploid type were found almost in the same number and those of hyperploid type were found only in a small number. In the later generations, however, the number of tumor cells of hyperploid type increased gradually. The chromosome number of hyperploid cells varied widely, showing a normal curve with the peak at about 110. Morphological analysis of the chromosomes revealed that the chromosome complex consisted mostly of rod-shaped chromosomes. Large V-shaped or large J-shaped chromosomes were found in about 30% of tumor cells examined.