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Studies on the experimental pseudotuberculosis by B. pseudotuberculosis rodentium in mice. II. Chiefly on the infection by intranasal route



Studies on the experimental pseudotuberculosis by B. pseudotuberculosis rodentium in mice. II. Chiefly on the infection by intranasal route



Saikingaku Zasshi 527: 53-67



The author observed the histological changes and the course of the disease in mice. When the mice were infected through either the intranasal or subcut. route, the inoculated bacilli invaded via the regional lymphatic glands, liver and spleen, where they proliferated and seemed partially to enter the blood stream. The maximum proliferation of the bacilli in these organs was attained during the 5-10-day period after inoculation. After that period, the disease showed either a chronic course or natural healing. Proliferation of the bacilli in the lungs took place in the chronic cases where the pseudotubercles formed. In the case of natural healing, the tubercles were also found even when the bacilli were negative.

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