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Studies on the intratypic variants of echoviruses II The role of cell receptors in the selection of echovirus variants



Studies on the intratypic variants of echoviruses II The role of cell receptors in the selection of echovirus variants



Acta Microbiol Acad Sci Hung: 283-298



The hemagglutinating strains of ECHO viruses lost their hemagglutinating capacity by passages in certain stable human cell lines. The presence of hemagglutinating (H+) and non-hemagglutinating (H-) virions was demonstrated in strains of ECHO virus 3, 6, 7, 12 and 19. The loss of hemagglutinating activity is due to the selective inhibition of the H+ virions. Both the cell lines of human origin and the human erythrocytes possess receptors reacting selectively with the H+ virions.

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