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Studies on the measurement of the intra-pulmonary gas distribution by the helium closed circuit method using changeable volume modification

Studies on the measurement of the intra-pulmonary gas distribution by the helium closed circuit method using changeable volume modification

Sci Repts Res Inst Tohoku Univ Ser C Medicine 2(1): 31-51

The values of mixing efficiency and slow space by these new modifications corresponded quite well with the values obtained by the constant volume modification. As far as quantitative measurement of the impairment of intrapulmonary gas distribution is concerned, slow space is more adequate than mixing efficiency, because the normal range of mixing efficiency in aged normals being quite wide, mixing efficiency could not well differentiate normals from patients with pulmonary emphysema. However, slow space was so markedly increased in patients with pulmonary emphysema or bronchial asthma that these patients were well differentiated from those with other pulmonary diseases. As an index for the clinical use to detect the impairment of intrapulmonary gas distribution, A He may be recommended.

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