Studies on the metabolism of -lipoic acid in childhood. I. Effect of protein and amino acid composition in the diet on the biosynthesis of protein-bound lipoic acid

Nakamura, Tsuneo; Kusunoki, Tomoichi; Konishl, Seizaburo; Kato, Hidehiko; Mibu, A.

J Vitaminol 11(1): 37-44

1965


Accession: 025584373

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Abstract
The effects of the portein and amino acid composition in the diet on the biosynthesis of protein-bound lipoic acid (the active form of lipoic acid for oxidative decarboxylation of ɑ-keto acids, such as pyruvic acid and ɑ-ketoglutaric acid) were observed. Decreased incorporation of lipoic acid into the total mitochondrial protein of rat liver was revealed in the low protein group. The incorporation of the acid/mg N of liver mitochondria of the low protein group was unexpectedly higher than that in the standard diet group. In the lysine-, tryptophan- or threonine-deficient group, the incorporation of lipoic acid into the mitochondrial proteins was decreased, but in the methionine- or phenylalanine-deficient group, almost the same incorporation was observed as the standard diet group.