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Chapter 25,586

Studies on the mitotic activity of the corneal epithelium. Methods. The effect of colchicine, ether, cocaine and ephedrin

Buschke, W.; Friedenwald, J.S.; Fleischmann, W.

Bull Johns Hopkins Hosp 73(3): 143-167

1943


ISSN/ISBN: 0097-1383
Accession: 025585179

The number and distribution of mitoses in the corneal epithelium of the rat were investigated in the living animal and under supravital conditions, and the rate of entrance into mitosis, and the duration of the mitotic cycle were computed. Colchicine arrests mitosis in metaphase but has little or no effect on the rate of entrance of cells into mitosis. In the corneal epithelium of the living rat, ether, cocaine, and ephedrin all diminish the rate of entrance of cells into mitosis. Under certain circumstances ether appears, in addition, to increase the duration of the mitotic cycle. The combined use of colchicine together with other drugs affords a simple means of distinguishing between possible effects of these other drugs on the rate of entrance into mitosis and on the duration of mitosis.

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