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Studies on the occupational environment and pathology of workers employed in malaria eradication. Chronic intoxication with hexachlorocyclohexane . III. Correlation between clinical, chronaximetric and bio-chemical disturbances



Studies on the occupational environment and pathology of workers employed in malaria eradication. Chronic intoxication with hexachlorocyclohexane . III. Correlation between clinical, chronaximetric and bio-chemical disturbances



Arch Mal Profess Med Travail Et Sec Soc 23(1/2): 18-31



The daily absorption of hexa- chlorocyclohexane in the normal course of work causes homeostasic organic malfunction manifested by clinical, chronaximetric, biochemical and hematologic phenomena, which are most varied and intense in the first 5 to 10 years of this work, but not severe enough to affect working capacity. Neurologic symptoms are the most characteristic of chronic HCH intoxication; other clinical symptoms may be of digestive, cutaneous, or respiratory type. There is a high frequency (84%) of associated clinical and chronaximetric phenomena. Biochemical and hematologic anomalies include changes in blood proteins and catalase, plasma cholinesterase, in hepatic antitoxic function and in bile excretion. There is a tendency to hypochromic anemia and leukopenia. Almost half of the workers (42.5%) had associated clinical, chronaximetric and biochemical abnormalities; most were on the job over 5 years. Physicals for job applicants should exclude all persons with chronic intoxication or organic disease. A diagnosis of chronic HCH intoxication should be based on length of toxic contact, absence of other toxic influences, and the existence of a combination of symptoms described above.

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