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Subacute bacterial endocarditis due to Salmonella typhimurium

Subacute bacterial endocarditis due to Salmonella typhimurium

British Medical Journal 2(4637): 1155-1155

A fatal case of subacute bacterial endocarditis due to S. typhimurium occurred in a woman, aged 19, who failed to show clinical improvement from penicillin therapy. A favorable reduction in the febrile state was noted following the use of chloramphenicol and, to a lesser degree, by streptomycin. In spite of treatment, the disease progressed unabated. The progress of the disease in this patient, irrespective of temp. reduction, suggests that a much higher maintenance dosage is required at the onset of treatment than is employed in typhoid fever (i.e., 1.5 g. of chloramphenicol every 3 hrs. instead of every 12 hrs.) and that this treatment should be continued for at least 28 days.

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Accession: 025605984

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PMID: 15396093

DOI: 10.1136/bmj.2.4637.1155

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