Home
  >  
Section 26
  >  
Chapter 25,612

Sulfated Insulin for Treatment of Insulin-Resistant Diabetics

Moloney, P.J.; Aprile, M.A.; Wilson, S.

Journal of New Drugs 4(5): 258-263

1964

ISSN/ISBN: 0096-0284
PMID: 14218619
DOI: 10.1002/j.1552-4604.1964.tb00356.x
Accession: 025611353
Download citation:  
Text
  |  
BibTeX
  |  
RIS
Sulfated insulins obtained by reaction of ox or pig insulin with H2SO4 had chemical and immunological properties very different from those of the parent insulin. The sulfated material was relatively non-neutralizable by antiserum against ox insulin, using the response of whole mice or mouse diaphragm tissue to indicate hormonal activity. It also reacted poorly with anti-ox-insulin serum in agar immuno-diffusion, complement fixation, and hemagglutination tests. Sulfated insulin was found to be much less antigenic in guinea pigs than unaltered insulin. Eleven insulin-resistant diabetic patients were brought under control with sulfated insulin at dosages which were always much lower, usually one-tenth to one-fifth, than those required when standard insulin preparations were employed. There was no tendency for the required dose of sulfated insulin to increase with prolonged therapy. As of June 1964, 5 cases were successfully treated for over 2 years. Two out of 5 patients who were allergic to ox and pig insulins were found to respond to sulfated insulin without unfavorable reactions. However, sulfated insulin showed no advantage over unaltered insulin for treatment of normal or unstable diabetics.

PDF emailed within 0-6 h: $19.90




Related References

Lev-Ran, A.; Ratt, L.; Gersht, N. 1975: Serum insulin, insulin antibodies and insulin requirement in the first period of insulin treatment in non-insulin resistant diabetics Acta Diabetologica Latina 12(1): 66-71
Csima, A. 1972: 4 year assessment of plasma insulin antibody content and avidity in diabetics treated with lente insulin or sulfated insulin Clinical Research: 945
Little, J.A.; Lee, R.; Sebriakova, M.; Csima, A. 1977: Insulin antibodies and clinical complications in diabetics treated for five years with lente or sulfated insulin Diabetes 26(10): 980-988
Mateo, M.C.G.; Hernandez, C.; Duran Garcia, S. 1985: Insulin receptor interaction beta cell function insulin requirements glycemic control and serum lipids in insulin dependent diabetics and non insulin dependent diabetics treated with guar gum Diabetes Research and Clinical Practice (Suppl 1): S199
Little, J.A.; Arnott, J.H. 1966: Sulfated insulin in mild, moderate, severe and insulin-resistant diabetes mellitus Diabetes 15(7): 457-465
Arnott, J.H.; Little, J.A. 1965: Sulfated insulin in mild, moderate, brittle and insulin-resistant diabetes mellitus Can Med J 92(7): 346-347
Gomis, R.; Novials, A.; Coves, M.J.; Casamitjana, R.; Malaisse, W.J. 1989: Suppression by insulin treatment of glucose-induced inhibition of insulin release in non-insulin-dependent diabetics Diabetes Research and Clinical Practice 6(3): 191-198
Hidaka, H. 1982: Effect of insulin treatment on insulin secretion and insulin resistance in obese type Ii diabetics Horumon to Rinsho. Clinical Endocrinology 30(7): 699-704
Bruns, W.; Jutzi, E.; Fischer, U.; Bombor, H.; Woltanski, K.P.; Jahr, D.; Wodrig, W.; Albrecht, G. 1981: Circadian variations in insulin concentrations and blood glucose in non-diabetics as well as insulin requirements in insulin-dependent diabetics Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 36(5): 258-260
Menczel, J.; Levy, M.; Bentwich, Z. 1966: Insulin resistant diabetes treated with sulfated insulin Israel Journal of Medical Sciences 2(6): 764-768
Solini, A.; Sambataro, M.; Piarulli, F.; Milan, D.; Dekreutzenberg, S.V.; Muollo, B.; Velussi, M.; Morocutti, A.; Barzon, I.; Nosadini, R. 1991: Type 2 non insulin dependent diabetics with hypertension and microalbuminuria are more insulin resistant than normotensive type 2 diabetics Diabetologia 34(Suppl 2): A19
Scott, A.R.; Attenborough, Y.; Peacock, I.; Fletcher, E.; Jeffcoate, W.J.; Tattersall, R.B. 1988: Comparison on high fiber diets basal insulin supplements and flexible insulin treatment for non insulin dependent type ii diabetics poorly controlled with sulfonylureas British Medical Journal 297(6650): 707-710
Páv, J.; Svacina, S.; Srámková, J.; Hilgertová, J. 1990: Compensation in diabetes and serum insulin levels in type i diabetics during insulin pump therapy and after changing to treatment with a combination of short- and long-acting insulin Casopis Lekaru Ceskych 129(19): 596-601
Scott, A.R.; Attenborough, Y.; Peacock, I.; Fletcher, E.; Jeffcoate, W.J.; Tattersall, R.B. 1988: Comparison of high fibre diets, basal insulin supplements, and flexible insulin treatment for non-insulin dependent (type II) diabetics poorly controlled with sulphonylureas Bmj 297(6650): 707-710
Gray, R.S.; Borsey, D.Q.; Irvine, W.J.; Duncan, L.J.; Clarke, B.F. 1983: Non-insulin-treated ICA positive and negative diabetics are equally insulin resistant Diabete and Metabolisme 9(4): 292-296