Susceptibility of aorta strips from rabbits with different types of experimental hypertension

Vacek, Lubor

The susceptibility of spiral cut rabbit thoracic aorta strips to epinephrine, histamine and serotonin was examined. The experiments were performed on aortae from normal rabbits, from animals with metacorticoid hypertension after desoxycorticosterone acetate and NaCl, from animals with blood pressure elevated by repeated doses of ephedrine, and from animals with renal type of hypertension produced by unilateral nephrectomy and by partial ligation of art. renalis on the other side. In metacorticoid hypertension, the susceptibility of aorta strips to epinephrine was increasedand remained unchanged to histamine. In renal hypertension there was no change in the susceptibility of aorta high blood pressure a more widespread reactive area was observed, i.e., there was a wider interval between the minimal and maximal effective doses. The cause of the observed differences is thought to be based upon altered metabolism in various types of experimental hypertension.