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Tachyphy-lactic reactions in cats, rats, and guinea pigs to certain anorexigens from the phenmetrazine and ephedrine series



Tachyphy-lactic reactions in cats, rats, and guinea pigs to certain anorexigens from the phenmetrazine and ephedrine series



Arch Internatl Pharmacodyn Ther 146(3/4): 463-474



Ephedrine, methylephedrine, phenmetrazine, phendimetrazine with its optical isomers, and phentrimetrazine were investigated with respect to their tachyphylactic reaction (T-reaction) on cat- and rat blood pressures, isolated guinea-pig atrium, and the caudal rat blood flow. Reaction strengths vary between substances and between species. Ephedrine causes a T-reaction in cats, guinea pigs, and rats in that order. Some evidence also exists for cross-T reactions between ephedrine and some phendimetrazine isomers, but the reactions were weak. Cats are sensitive (positive T-reaction) to ephedrine, phendimetrazine, and trimetrazine. Rats were sensitive to ephedrine only, and the guinea pig atrium to both ephedrine and phenmetrazine.

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Accession: 025637306

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