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The carbon monoxide diffusion capacity of the lung in normal subjects



The carbon monoxide diffusion capacity of the lung in normal subjects



Australasian Ann Med 7(3): 192-204



CO diffusing capacity was studied in 29 normal subjects, the method differing only in detail from the steady state method of Filley. Mean value was 22 at rest, a higher value than found by others using similar methods. Diffusing capacity doubled on severe exercise and no plateau of Dco occurred. No correlation with body size or lung volumes could be shown. The mean figure is less than that found by others using breath-holding techniques. Steady state methods underestimate the Dco due to fallacies in the use of the Bohr equation and due to build-up of carboxyhemoglobin. If these are allowed for, the present results approach more nearly those obtained by breath-holding methods.

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Accession: 025697579

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PMID: 13584265


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