The chemical structure of human brain and Tay-Sachs gangliosides
Biochem And Biophys Res Commun 9(5): 436-441
Normal human brains contain mono- and disialogangliosides, the second of which can be converted to the major monosialoganglioside by enzymic hydrolysis with neuraminidase. Partial acid degradation of the monosialoganglioside has given 4 neutral ceramide-saccharides. The ganglioside accumulated into the brain in Tay-Sachs disease has been shown to lack the galactose in end position.