The Clinical Significance of the Ocular Musculature: With Special Reference to the Intra-Ocular Pressure and the Circulation of the Intra-Ocular Fluid
Duke-Elder, W.S.; Duke-Elder, P.M.
British Journal of Ophthalmology 16(6): 321-335
ISSN/ISBN: 0007-1161 PMID: 18169035 DOI: 10.1136/bjo.16.6.321
Using the perfusion method in their work on the dog's eye, the authors conclude: (1) Involuntary light pressure from lid muscles, such as occurs in the action of blinking, raises the intra-ocular pressure by 5 mm. Hg (from 27 to 53). (2) The normal tone of the muscle of the globe is responsible for the maintenance of almost one-half the normal intra-ocular pressure. When an injection of curare is given while blood pressure is maintained at a constant level, a profound fall of the intra-ocular pressure results. A contraction of these muscles following intravenous injections of choline or eserine has the opposite effect. (3) The stimulation of the sympathetic increases the intra-ocular pressure due to the action of the muscle of Muller. A reverse effect is produced by decreasing the tone of the plain muscle following the administration of atropine.[long dash]Intravenous injection of nicotine, which stimulates both the voluntary and in-voluntary muscles of the orbit, increases the intra-ocular pressure.