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The distribution of labelled 7,12-dimethyl benz anthracene in the tissues and organs of rats and its excretion from the body



The distribution of labelled 7,12-dimethyl benz anthracene in the tissues and organs of rats and its excretion from the body



Vop Onkol 10(4): 41-47



By means of the labeled atom method, the distribution of 7.12-1 dimethylbenz ([alpha] ) anthracene (DMBA) is studied in the tissues of the mammary gland and internal organs as well as the excretion of its derivatives with milk, urine, feces and expired carbonic acid. DMBA, injected intravenosuly, is quickly excreted out of the body with the bile, feces, urine and milk. The greatest part of all the injected radioactivity is excreted with urine and feces within one week. If DMBA is injected once or 3 times, no selective accumulation of this preparation is observed in the mammary gland tissues.

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