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The effect of ambient temperature on the actions of tremorine on body temperature and on the concentration of noradrenaline l_norepinephrinej, dopamine, 5-hydroxytryptamine and acetylcholine in rat brain



The effect of ambient temperature on the actions of tremorine on body temperature and on the concentration of noradrenaline l_norepinephrinej, dopamine, 5-hydroxytryptamine and acetylcholine in rat brain



Brit J Pharmacol Chemother 31(2): 356-366



Tremorine increased brain acetylcholine and decreased brain norepinephrine; both effects were independent of the ambient temperature. No change in brain dopamine was observed at any temperature. Tremorine-induced increase in brain 5-HT was only seen at ambient temperatures less than 26[degree]C, when the rectal temperature fell 3[degree]C or more. The tremorine-induced hypothermia was greater the lower the ambient temperature. At 36[degree]C, tremorine increased rectal temperature and its toxicity was increased.

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Accession: 025741477

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