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The effect of copper and manganese on the blood pyruvic-acid and reduced glutathione concentration with painful stimulation in dogs



The effect of copper and manganese on the blood pyruvic-acid and reduced glutathione concentration with painful stimulation in dogs



Uch Zap Petrozavodskogo Univ 13(3): 98-101



Painful stimulation was induced in dogs by sticking the lower third of the left leg with a needle or by the passage of an electric current (12 v, 0.5 ma) for 30-60 sec. at 1-sec. intervals. Under the action of such stimili there was an increase in the concentration of pyruvic acid (I) and SH-glutathione (II) in blood. If, 1 hr. previously, the dogs were given 2 mg/kg of Cu as CuSO4 or Mn as MnCl2, there was a decrease in this effect of painful stimulation. Thus, both trace elements prevent a rise in pyruvic acid and SH-glutathione concentrations of the blood which is caused by painful stimulation.

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