The effect of drug-induced sleep on erythropoiesis during a post-hemorrhagic period
Russian and English Summ Fiziol Zhur 4(3): 339-347
Effect of drug-induced sleep on erythropoiesis (E) following hemorrhage was studied in 110 rabbits. Rabbits to which Nembutal (pentobarbital) barbamyl (amo-barbital), Medinal (barbital sodium), urethane or chloral hydrate was administered, slept for 8-10 hours a day during 7-10 days. Some rabbits were given one of the above drugs 60 minutes after bleeding, others were given the drug 1 hour before the bleeding. Sleep had a protective effect against anemia, and an inhibitory effect on (E). After blood loss amounting in approximately 30% of the total blood volume, sleep induced by drugs suppressed the process of blood content recovery. Sleep induced by means of drugs prior to bleeding decreased the anemia on the first day, and partly on the second, but afterwards even in these experiments the drug suppressed hemopoiesis. The inhibitory effect of sleep induced by drugs on (E) was clearly pronounced during later stages of anemia, when apparently the suppression of activity of the stimulant through protective inhibition was completed. During the period of protective inhibition the suppressant effect of sleep induced by drugs on E was masked. However, even during this period it could be detected by determining the total number of reticulocytes (R). In control animals, both the absolute and relative number of (R) increased during the first days after bleeding. In rabbits which received sleeping pills, the absolute number of (R) during this period even decreased. Barbamyl inhibited (E) to a greater extent than the other hypnotic drugs.