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The effect of dysentery bacteriophage on the course of experimental cystitis produced in guinea-pigs by Shigella flexneri



The effect of dysentery bacteriophage on the course of experimental cystitis produced in guinea-pigs by Shigella flexneri



Journal of Hygiene, Epidemiology, Microbiology, and Immunology 9(4): 455-459



Guinea-pigs were infected with a virulent culture of Shigella flexneri in several experimental variants. Infection led to the development of severe dysenteric cystitis, resulting in the death of most of the animals. The use of dysentery bacteriophage for the treatment and prevention of shlgellar cystitis did not produce positive results. The authors attribute the inefficacy of bacteriophage to the fact that dysentery bacteria proliferate intracellularly, in the epithelial cells, in the infected organism.

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Accession: 025748222

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PMID: 5893861



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