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The effect of intermittent anoxia on the brain



The effect of intermittent anoxia on the brain



Journal of Pathology and Bacteriology 64(2): 265-271



Using a carefully standardized histological technic, 2 anoxic abnormalities, enlarged pericellular and perivascular spaces, and chronic nerve cell change, were found to a greater or lesser extent in 48 normal guinea pig brains. The chronic nerve cell change could be associated with post-mortem mechanical injury to the brain, the cells of the Vth layer of the cerebral cortex being most vulnerable and often showing changes when the injury was some distance away. In 40 guinea pigs subjected to short immersions in N2 twice daily, specific changes due to the anoxia were detected in 2 animals only. In these there was an acute edematous cell change which was not present in animals allowed to survive for 10 days after their anoxic bouts. 10 animals received 60 immersions in N2 within 8 hrs. and no pronounced histological change was found although 3 of the animals showed neurological disturbances for a short time. Thus unconsciousness for 30 sec. produced with N2 twice daily for 30 days exerts no histologically demonstrable cumulative effect. A similar number of immersions in 1 day gave clinical but not histological evidence of accumulation.

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Accession: 025753694

Download citation: RISBibTeXText

PMID: 14946649

DOI: 10.1002/path.1700640203



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