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The effect of roentgen irradiation on the uptake of radioactive phosphorus into the acid-soluble compounds of transplanted mouse mammary carcinoma



The effect of roentgen irradiation on the uptake of radioactive phosphorus into the acid-soluble compounds of transplanted mouse mammary carcinoma



Cancer Research 20: 292-296



Mice bearing transplanted mammary carcinoma were irradiated with 4500 roentgens (in air) to the tumor. These and an equal number of un-irradiated controls were injected with radioactive P (1 [mu]c/g body weight). After 2 hr. the mice were killed, the tumors frozen in liquid N and extracted by homogenization with perchloric acid. Resolution of the P compounds in the neutralized extracts was carried out by gradient elution from Dowex 1 anion exchange resin columns with formic acid and ammonium formate buffers. A considerable part of the radio-activity passed through the columns and contained phosphorylenthanol-amine among several other P compounds. Twenty-four P compounds were eluted from the columns and the relative specific activities (r.s.a) of the main ones were determined. There was no difference between the r.s.a. of the monophosphonucleotides of the irradiated and the un-irradiated tumors. The r.s.a. of the polyphosphonucleotides of the irradiated tumors were lower than those of the unirradiated.

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Accession: 025761599

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PMID: 14441060


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