The effect of steroid hormones on lysosomal activity of rat ventral prostate gland in culture

Lasnitzki, I.; Dingle, J.T.; Adams, S.

Experimental Cell Research 43(1): 120-130


ISSN/ISBN: 0014-4827
PMID: 4288104
DOI: 10.1016/0014-4827(66)90385-5
Accession: 025763770

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The observed sedimen-tation and latency of acid protease, p-nitrophenol phosphate phosphatase and arylsulphatase of the rat prostate are consistent with the association of these enzymes with lysosomal particles. The regressive biochemical and histological changes seen in glands cultured in vitro in the absence of hormones or in the presence of estradiol are accompanied by increased p-nitrophenol phosphate phosphatase activity. Testosterone and hydrocortisone treatment was found to diminish these changes. It is suggested that lysosomal enzyme activity of the prostate may be under direct hormonal control.