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The effect of thyroidectomy and administration of anterior pituitary extract of cattle on the growth of cartilage and bone of immature guinea pigs



The effect of thyroidectomy and administration of anterior pituitary extract of cattle on the growth of cartilage and bone of immature guinea pigs



American Journal of Pathology 16(4): 505-524.3



Thyroidectomy in immature guinea pigs exerted a direct effect on the growth zones. It caused an accelerated sclerosis of the cartilaginous ground substance and inhibited the complete differentiation of columnar cartilage cells into hypertrophic cartilage cells. Proliferation of the cartilage cells was maintained and occasionally temporarily increased. Endochondral ossification was secondarily affected because of the inadequate supply of mature cartilage cells available for ossification. At later stages the amt. of osseous substance in the shaft of the long bones showed little deviation from the normal. This may be due to a decreased resorption balancing a possible decrease in apposition of osseous material rather than to a complete lack of influence of thyroid deficiency on periosteal and trabecular bone formation. The changes in cartilage and bone may be partly due to the lowered metabolism existing in hypothyreotic conditions; however, the temporary increase in the proliferation of the epiphyseal cartilage may be a consequence of the stimulation of the anterior pituitary gland subsequent to thyroidectomy. Ant. pituitary extract of cattle exerted its influence on cartilage and bone in guinea pigs in which the thyroid gland has been completely or almost completely removed. Under these circumstances increased growth and retrogressive changes in the cartilage, followed by an enhanced ossification, took place. However, the differentiation of the cartilage remained incomplete after thyroidectomy, even if ant. pituitary hormone was administered, and normal conditions were not restored. There takes place, therefore, under these conditions, a summation of the effects of thyroidectomy and ant. pituitary hormone.

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Accession: 025767307

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PMID: 19970520


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