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The effects of implanting heterogenous compact and cancellous anorganic bone into the long bones of rabbits



The effects of implanting heterogenous compact and cancellous anorganic bone into the long bones of rabbits



Archives of Oral Biology 11(11): 1117-1127



Defects of standard size were prepared in the long bones of rabbits. Some defects received no implant and served as controls others were filled with (a) compact bovine anorganic bone prepared by ethylenediamine extraction, (b) similar material that had been broken into fragments, or (c) cancellous bovine anorganic bone prepared by extraction with hydrogen peroxide and ethylenediamine. The animals were killed after periods ranging from 1 to 16 weeks, and the bone defects were studied histologically. In groups (a) and (b) the patterns of healing were similar to those found in an ealier series of experiments in sheep. Both species showed the same lack of resorption of the anorganic bone so that the material became incorporated in new bone but constituted an obstruction to complete repair. The cancellous anorganic bone, which had been prepared by a different method, behaved in the same way, although the cancellous structure provided more space for new bone formation. Defective healing, apparently attributable to marrow herniation, was seen in many control defects, but the herniation was prevented by all 3 types of implant.

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Accession: 025774451

Download citation: RISBibTeXText

PMID: 5335234

DOI: 10.1016/0003-9969(66)90169-5


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