The effects of various antibiotics upon the coagulase activity of antibiotic-resistant and antibiotic-sensitive Staphylococcus strains

Boniece, W.S.; Holmes, D.H.; Wick, W.E.

Antibiotics and ChemoTherapy 6(9): 550-553


ISSN/ISBN: 0570-3123
PMID: 24544093
Accession: 025777687

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The effects of erythromycin, tetracycline, chloramphenicol, streptomycin, and penicillin on the in vitro coagulase activity of 4 antibiotic-resistant and 2 antibiotic-sensitive Staphylococcus strains were studied. Significant inhibition by erythromycin of the coagulase activity of the resistant cultures was found at levels quite far below the minimum inhibitory concentrations. These levels are readily attainable clinically. Increases in the plasma clotting times resulted also from the addition of tetracycline or chloramphenicol. However, in the case of the resistant cultures, these increases were generally not so pronounced as those produced by erythromycin. Streptomycin had slight to moderate effects upon the coagulase activity of half the strains, but only at the highest levels tested. No increases in the clotting times resulted from the addition of penicillin.