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The formation of microscopic plaques by herpes simplex virus in HeLa cells

The formation of microscopic plaques by herpes simplex virus in HeLa cells

Virology 6(2): 317-327

Certain characteristics of this host virus system have so far prevented macroscopic plaque formation under agar. Microscopic plaques are formed, however, and proportionality exists between plaque numbers and virus input. The efficiency of plaque formation was influenced by the inoculum size and the adsorption period. The relative sensitivity of HeLa cells for herpes virus titrations is discussed.

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Accession: 025796701

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PMID: 13593174

DOI: 10.1016/0042-6822(58)90085-0

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