The in vitro effect of two oral hypoglycemic agents on hepatic protein synthesis

DeChatelet, L.R.; McDonald, H.J.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 122(3): 765-768


ISSN/ISBN: 0037-9727
PMID: 5918947
DOI: 10.3181/00379727-122-31247
Accession: 025817721

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Leucine-C14 was utilized to study the affects of 2 oral hypoglycemic agents (tolbutamide and phenethylbiguanide) on protein metabolism. Both compounds were seen to inhibit C14O2 production and incorporation of the amino acid into protein by rat liver homogenate. Differences in the mode of inhibition are noted and discussed. Neither compound appears to be dependent on the presence of glucose for its in vitro affects on protein metabolism.