The in vitro effect of DDT and related compounds on the succinoxidase system of rat heart

Johnston, C.D.

Archives of Biochemistry and Biophysics 31(3): 375-382


ISSN/ISBN: 0003-9861
PMID: 14830251
Accession: 025817723

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DDT (2,2-bis-(p-chlorophenyl)-l,l,l,-trichloroethane); DDT dehydrochloride (2,2-bis-(p-chlorophenyl)-l,l-dichloroethylene), methoxychlor (2,2,-bis(p-methoxyphenyl)-l,l,l-trichloroethane), methoxychlor dehydrochloride (2,2-bis-(p-methoxyphenyl)-l,l-dichloroethylene) and DDA (4,4-dichlorodiphenylacetic acid) were dissolved in ethanol and tested for inhibitory effects on rat heart succinoxidase prepns. at 10-4 to 10-5 M concns. All but DDA were inhibitory. Cytochrome oxidase was also inhibited, but succinic dehydro-genase was not. DDT in oil emulsion was without effect on the succinoxidase system. Since succinic dehydrogenase and cytochrome oxidase are both associated in cell particles, it seems unlikely that DDT toxicity is due to nonspecific physical blockage of cell surfaces.