The influence of prolonged sleep upon the disorders in the higher nervous activity induced by staphylococcal intoxication during the period of predomination of excitation and inhibition in white rats
Trudy Instituta Vysshei Nervnoi Deiatel'nosti Transl Pathophysiological Ser p 216-239
The standard staphylococcal toxin, subcutaneously introduced in the animals in doses of 2.0 ml/kg, induces a series of complex and protracted disorders in the activity of the higher areas of the central nervous system. Though the course of these disorders is somewhat different from those induced by the 5.0 ml per 1 kg animal weight dose, yet there are also basic similarities between these two courses of disorders. Namely: in the disorders of the motor coordination, in the alterations of the complex unconditional reflexes, as well as exopthalmus, bristling, dyspnea, dermodistrophial phenomena. During the first period of intoxication, under the influence of the 2.0 ml/kg doses of staphyloccal toxin, the diffuse inhibition together with phasic phenomena develop in the animals' cortical activity. In the following, these phenomena are replaced by the predomination of the excitation. Further on, either a gradual normalization of the conditional reflexes sets on, or the inhibition and phasic phenomena step in together with other disorders of the cortical activity. A temporary normalization of the conditional reflex activity is observed in some of the animals during this first period of the intoxication. The prolonged (4-day) sleep induced by sodium-amytal and applied at various periods of the intoxication does not give similar results. While the conditional reflex activity of the animals subjected to the course of sleep therapy, during that period of intoxication when the diffuse inhibition predominated, was normalized soon after the termination of the sleep therapy[long dash]there was not a complete normalization, in most cases, of the higher nervous activity of the animals subjected to the prolonged sleep during the period when the excitation predominated in the cortex. In consequence, the prolonged sleep has a positive influence upon the course of the staphylococcal intoxication under the condition that it is applied during the period of the diffuse, protective inhibition.