Section 26
Chapter 25,831

The influence of the intraluminal intestinal milieu on absorption of an organic cation and an anionic agent

Levine, R.R.

Journal of Pharmacology and Experimental Therapeutics 131: 328-333


ISSN/ISBN: 0022-3565
PMID: 13761504
Accession: 025830256

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Various agents, such as amino acids, bile and bile salts, hexose acids and sorbitol, had no effect on the in vivo absorption of benzomethamine, a quaternary ammonium drug. Hyaluronic acid, chrondroitin sulfate, sodium metaphosphate, and calcium chloride significantly decreased the per cent of the onium absorbed from intestinal loops. Only the saturated water-soluble fatty acids, acetic, propionic and butyric, increased the absorption of benzomethamine. These acids had this facilitory effect only when added to the medium in relatively high concentrations (0.2 [image]) and at relatively low pH. However, this increased absorption was shown not to be simply the result of an acidic intestinal environment or irreversible changes in the gut wall. The in vivo absorption of phenol red was also investigated. A new simple method for the accurate determination of phenol red in tissue was developed and is described. Phenol red is absorbed to the extent of 7.1 [plus or minus] S. D. 1.04%. Butyric acid, 0.2 [image], pH 2.9, significantly increased the absorption of phenol red and again this was not merely the result of the acidic medium.

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