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The involvement of mitochondria in the control of glycolysis in the nucleus



The involvement of mitochondria in the control of glycolysis in the nucleus



Dokl Akad Nauk Sssr 154(5): 1202-1205



A study was made of the influence of the control system of the mitochondria on the glycolytic system of the nucleus by investigating the effects of glycolysis stimulating factors on isolated nuclei and nuclear extracts. Mitochondria were obtained from rat liver and rabbit heart, while nuclei were obtained from rat thymus. Un-fractionated mitochondrial "secretion" stimulated glycolysis in the nuclear extract; this effect was observed both in the presence and absence of coenzymes. In the absence of coenzymes, it is the nucleotide fraction of the "secretion" which stimulates glycolysis, while in their presence, the stimulating effect resides in the protein fraction. It is thought that in the intact cell, the nucleotide fraction acts first, while the action of the protein fraction begins upon coenzyme saturation. The rate of glycolysis also increases upon addition of kinazin (the lipoprotein active principle of the protein fraction), which is known to stimulate hyaloplasmic glycolysis. Similar results were obtained with intact nuclei. These data indicate that the mitochondrial control system of glycolysis operates on a cell-wide scale.

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