The nature of course of the infection caused by antibiotic-resistant and antibiotic-sensitive strains of Staphylococcus aureus in mice

Moroz, A.F.

Zhur Mikrobiol Epidemiol I Immunobiol Transl 31(7): 1270-1275


Accession: 025863822

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Animals infected with drug-resistant strains of Staphylococcus aureus isolated from patients during treatment with antibiotics eliminated the organisms much later than animals infecsted with the original antibiotic-sensitive strains. The above strains caused a severe and protracted infection which in a number of cases was accompanied by the formation of abscesses in some organs. Mice infected experimentally with staphylococci obtained in in vitro experiments and highly resistant to a number of antibiotics (penicillin, streptomycin, chlortetracycline, oxytetracycline, tetracycline and erythromycin) also eliminated the organisms much later than animals infected with the original antibiotic-sensitive strain. Staphylococci which acquired resistance to aurantin (3 strains), mycerin (1 strain) and oxytetracycline (1 strain) were rapidly eliminated from the body of the infected animals.