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The oxidative decomposition of urocanic acid by rabbit liver enzymes. II. Isolation of the metabolic intermediates



The oxidative decomposition of urocanic acid by rabbit liver enzymes. II. Isolation of the metabolic intermediates



Kumamoto Med Jour 11(3): 189-201



Urocanic acid is oxidized with more than 1.6 atoms oxygen per mole substrate to eventually produce CO2, NH3, and glutamic acid for about .3 mole. Tentatively, the main sequence of the oxidative decomposition of urocanic acid in rabbit liver is [forward arrow] imidazoloneacrylic acid [forward arrow] isoaminogoutaconic acid amide [forward arrow]hydroxy-isoglutamine.

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