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The role of the liver in acute anaphylactic shock in the guinea pig



The role of the liver in acute anaphylactic shock in the guinea pig



Jour Immunol 32(5): 409-413



Male and [female] guinea pigs were sensitized by the intra-peritoneal injection of sheep serum and a period allowed to elapse for the development of adequate hyper-sensitiveness. Anaphylaxis was then induced by the intraven. administration of the antigen. In the normal animals the response was observed in 15-60 sec. and death occurred in 5-11 min. Removal of the abdominal viscera from such sensitized guinea pigs did not effect the onset or development of the anaphylactic reaction. These observations make it obvious that neither the liver, spleen nor other abdominal viscus is essential for acute anaphylaxis in the intact guinea pig.

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Accession: 025926818

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