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The treatment of hypertensive disease with modern hypotensive drugs Hypertensive disease. Coronary atherosclerosis



The treatment of hypertensive disease with modern hypotensive drugs Hypertensive disease. Coronary atherosclerosis



The treatment of hypertensive disease with modern hypotensive drugs Hypertensive disease Coronary atherosclerosis Lechenie giper-tonicheskoi bolezni sovremennymi gipotenzivnymi sredstvami In: Gipertonicheskaya bolezn' Koronarnyi ateroskleroz Hypertensive disease Coronary atherosclerosis 15-28



This review presents the comparative results of treatment of patients with hypertensive disease by 4 different groups of hypotensive agents: those of central action (bromides, barbiturates, magnesium sulfate, meprobamate, depressin [Contains nembutal, dibazole, reserpine, and hydrochloro-thiazide.[long dash]Transl.], and also dibazol, Rauwolfia, and derivatives of hydrazinophthalazine); ganglionic blocking agents (hexamethonium, pempidine compounds); drugs of peripheral sympatholytic action (guanethidine and to some extent reserpine); and inhibitors of enzymes participating in catecholamine and serotonin [5-hydroxytryp-tamine] metabolism ([alpha]-methyldopa). Consideration is given to the indications for the use of different hypotensive drugs and their side effects. An increase is noted in the number of favorable cases of treatment of hypertensive disease in the past several years (up to 60% using hexamethonium and up to 90% using guanethidine preparations). Wide use is recommended of combined preparations which make it possible to lower the dosage of the individual components and reduce side effects when there is marked hypotensive action.

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