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Time factor in ovulation blockade in rats under differing lighting conditions



Time factor in ovulation blockade in rats under differing lighting conditions



Endocrinology 80(4): 790-792



Adult 4-day cyclic rats of the Charles River CD strain, illuminated daily from 6:00 to 18:00 E.S.T., were compared with similar rats illuminated from 5:00 to 19:00. Pentobarbital sodium (31.5 mg/kg ip) was injected at different times during the afternoon of the day of proestrus; its effectiveness in blocking ovulation was determined at autopsy the following morning. No difference was noted between animals of the 2 groups. Compared with the locally inbred Osborne-Mendel rats, CD rats show a longer "critical period," beginning before 13:30 and lasting beyond 17:00.

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Accession: 025991087

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PMID: 6067084

DOI: 10.1210/endo-80-4-790


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