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Transfer of chemical substances from the vascular system into the tissues



Transfer of chemical substances from the vascular system into the tissues



Arch Exp Path U Pharmakol 111(1/2): 42-59



Perfusion experiments were made with the hind legs of frogs. The concentration of the test substance was measured continuously in the effluent solution, any loss being ascribed to transfer into the tissues. Unless the substance was combined with or destroyed by the tissues, an equilibrium distribution of it between the fluid and tissues was to be expected, provided that it could penetrate the walls of the vessels. Combination of the substance with or destruction of it by the tissues would delay or prevent equilibrium. Such experiments with a non-penetrating dye, Congo red, showed no further change in concentration after 4-6 minutes. NH4C1, urea, and glucose penetrated easily, since there was no further change after 2-5 hours. The amino acid dioxyphenylalamine was also easily taken into the tissues (no change after 5 hours); hence the tissues were unable to destroy this substance, which is easily oxidized outside the body. Alkaloids (determined nephelo-metrically) likewise penetrated easily but with the majority of those tested equilibrium was not attained in 20 hours or longer, indicating that they were either quickly destroyed or, more probably, combined with tissue constituents. Dialysis experiments showed that certain alkaloids passed much less completely into salt solution from horse serum than from distilled water. With other alkaloids in perfusion experiments, equilibrium was reached in 5 hours or less. In perfusion experiments with adrenalin the concentration change was complete in 2 hours, the same result being obtained with an isolated leg preparation of a warm-blooded animal. Hence adrenalin was not destroyed in the muscular tissue of either warm or cold blooded animals. In experiments with the liver of warm blooded animals a large capacity for destroying adrenalin was found, no equilibrium in the concentration of the flowing solution being attained. Glucosides penetrated the walls of the blood vessels easily, but were not digested by the tissues.

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