Untersuchungen uber den Mechanismus der alimentaren Hyper-glykamie. I. Blutzuckeruntersuchungen nach peroraler und intraduodenaler Glucosebelastung. II. Experimentelle Untersuchungen uber die Resorptionsgeschwindigkeit der Glucose im Dunndarm. III. Experimentelle Untersuchungen uber den Blutzuckergehalt verschiedener Gefass-bezirke nach intraduodenaler Glucosebelastung

Meythaler, F.; Seefisch, H.

Arch Exp Path U Pharmakol 178(4/5): 461-466

1935


Accession: 026052203

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Abstract
I. After peroral or duodenal introduction of glucose in humans or dogs with normal metabolism, a slight increase of peripheral blood sugar is seen in the first 5 min., followed by a slight decrease for 8-10 min. In patients with gastric ulcer who have been long fed by duodenal tube, the same is seen, though more pronounced. The normal course of the glycemic reaction is held to be: (1) alimentary prehyperglycemia, (2) alimentary prehypo-glycemia, (3) alimentary hyperglycemia, (4) posthyper-glycemic hypoglycemia.-II. Directly introduced sugar (duodenal injection) in somnifen-anaesthetized dogs is absorbed in 1 min. In a few cases stoppage of absorption between the 5th and 15th minute is seen, ascribed to a rhythm of tonus of the mucous membrane of the small intestine. With stronger sugar solutions, rhythm in the course of absorption is more pronounced. The time of beginning absorption does not depend on the concn. of sugar solution nor is there a relation of blood sugar level to the speed and intensity of absorption.-III. For 1 hr. after duodenal introduction of sugar the blood sugar of blood from the vena cava inf., v. portae, v. hepatica (and in some cases the A. femoralis) was assayed in repeated order at short intervals. Sugar absorption in the small intestine, leading to increased blood sugar in the v. portae, begins in the 1st min. after introduction. The speed of absorption is not dependant on the hungry or fed condition of the animal. The blood sugar of the v. hepatica always remains lower than that of the v. portae. Hence sugar is retained in the liver. The glycopexic power of the liver depends on its initial glycogen content and is increased in hunger. The difference between the blood sugar levels in the blood from the v. hepatica and from the v. cava inf. represents sugar retained in the periphery. Alimentary hyperglycemia depends chiefly on absorption conditions; the effect of insulin secretion is secondary.