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Urinary;pantothenate, blood glucose and inorganic serum phosphate in patients with metabolic disorders treated with high doses of pantothenate



Urinary;pantothenate, blood glucose and inorganic serum phosphate in patients with metabolic disorders treated with high doses of pantothenate



Jour Nutrition 39(1): 107-116



The daily excretion of pantothenic acid was studied in patients with diabetes, Addison's disease, cirrhosis of the liver, and chromophobic tumor of the pituitary. On a normal diet the excretion of pan-tothenic acid in all subjects varied from 2.6 to 8.6 mg. per 24 hrs. When Ca pantothenate was added to the diet the daily excretion rose so that at least 9% of the ingested pantothenate was excreted. When panthenol was the source of pantothenate, the excretion of pantothenic acid was still further increased. Insulin and glucose given intraven. did not affect the excretion of pantothenic acid in any of the patients studied. The blood levels of glucose and inorganic phosphate, determined following the intraven. admn. of glucose or insulin, were not influenced by large daily doses of Ca pantothenate.

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