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Cortisol and cortisone levels in umbilical cord plasma and maternal plasma of normal pregnancies

Cortisol and cortisone levels in umbilical cord plasma and maternal plasma of normal pregnancies

Steroids 21(4): 497-510

A method for assaying cortisol and cortisone using chromatography on either paper or Sephadex LH-20 columns for isolation, followed by competitive protein binding, has been applied to umbilical cord and maternal plasma samples. In mixed cord plasma the mean cortisol concentration was 6.0 ± 0.8 g/100 ml (n = 9) and the mean cortisone concentration was 13.5 ± 2.9 g/100 ml (n = 9). In cord arterial plasma the mean cortisol concentration was 6.3 ± 2.9 g/100 ml (n = 6) and the mean cortisone level was 10.1 ± 2.5 g/100 ml (n = 6). For cord venous plasma, the mean level of cortisol was 5.6 ± 1.5 g/100 ml (n = 6) and of cortisone was 13.5 ± 2.4 g/100 ml (n = 6). Maternal plasma gave a mean value of cortisol of 42.3 ± 4.5 g/100 ml (n = 6) and of cortisone of 6.2 ± 0.9 g/100 ml. The results of this study suggest that the fetus at term-gestation produces cortisol. The significance of this production compared with placental transfer of maternal cortisol into the fetal circulation however is uncertain.

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Accession: 026341257

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PMID: 4735482

DOI: 10.1016/0039-128x(73)90040-8

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