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Effect of ethimizole on content of cyclic amp in brain tissue



Effect of ethimizole on content of cyclic amp in brain tissue



Bulletin of Experimental Biology and Medicine 79(3): 274-276



It was shown by the use of an enzymic method of determining cyclic 3,5-adenosine monophosphate (cyclic AMP) that ethimizole more than doubles the concentration of this substance in the rat brain tissue 20 min after intraperitoneal injection in a dose of 25 mg/kg. Characteristic changes of carbohydrate metabolism associated with an increased cyclic AMP were found in the brain: a decrease in the glycogen content and an increase in the glucose content. It is concluded that the mechanism of action of ethimizole is connected with increased formation of cyclic AMP in brain tissue.

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Accession: 026470682

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DOI: 10.1007/bf00804213


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