Effects of electrical stimulation of the lateral hypothalamus, hippocampus, amygdala and olfactory bulb on unit activity of the lateral habenular nucleus in the rat

Mok, A.C.; Mogenson, G.J.

Brain Research 77(3): 417-429


ISSN/ISBN: 0006-8993
PMID: 4851746
DOI: 10.1016/0006-8993(74)90631-3
Accession: 026516886

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(1) In 56 male albino rats under urethane anesthesia, the effect of stimulation of the lateral hypothalamus, olfactory bulb, hippocampus and amygdala on unit activity of 261 lateral habenular neurons was studied.(2) Lateral hypothalamic stimulation influenced 58 (77%) out of 75 units in which activation was observed in 18 units, activation-inhibition in 29, inhibition in 8 and inhibition-activation in 3.(3) Olfactory bulb stimulation influenced 49 (49%) out of 102 units in which activation was observed in 25 units, activation-inhibition in 3, inhibition in 19 and inhibition-activation in 2.(4) Stimulation of the hippocampus influenced 36 (55%) out of 65 units in which activation was observed in 13 units, activation-inhibition in 6, inhibition in 12, inhibition-activation in 5.(5) Stimulation of the anygdala influenced 46 (66%) out of 70 units in which activation was observed in 17 units, activation-inhibition in 10, inhibition in 14, and inhibition-activation in 5.(6) Convergence and interaction of inputs from the hippocampus and amygdala were studied in 45 units in which 23 (51%) received converging inputs. Of these, 9 were inhibited and 4 activated by stimulation of both sites, 4 were activated by stimulation of the hippocampus and inhibited by stimulation of the amygdala.(7) The present study suggests that the lateral habenular nucleus serves as an integrating area for limbic forebrain inputs.